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Now here is where I got confused. I was certain AIR would be an option under the New menu. Nope. Instead, AIR is a per site setting. Thanks to the Adobe docs (Create your first HTML-based AIR application with Dreamweaver - note that that link is for AIR 1.5 - there is probably a link for the newer version but I don't think the actual process in DW has changed). So basically - you would make a new site and then simply configure the AIR settings.
Note that the settings menu is also where you generate the AIR file to ship. If you want to run the AIR file while testing, you use the Preview/Debug in Browser icon:
By the way, the ugly red circle is my awesome attempt at making it clear what icon I meant.
So in general - that's it. One big thing that Aptana does much better is the inclusion of the AIRAliases.js file. I had to manually copy that from the AIR SDK folder. Once I did and included it within my HTML template DW did a darn good job with autocomplete and hinting. I was also very surprised to see that DW supported displaying air.trace statements. It shows up in a panel called "Site Reports" which seems oddly named. Here's an example where I traced the word "ran":